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"On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue; and equal blame belongs to those who fail in their duty through weakness of will, which is the same as saying through shrinking from toil and pain. These cases are perfectly simple and easy to distinguish. In a free hour, when our power of choice is untrammelled and when nothing prevents our being able to do what we like best, every pleasure is to be welcomed and every pain avoided. But in certain circumstances and owing to the claims of duty or the obligations of business it will frequently occur that pleasures have to be repudiated and annoyances accepted. The wise man therefore always holds in these matters to this principle of selection: he rejects pleasures to secure other greater pleasures, or else he endures pains to avoid worse pains."

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"At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus. Temporibus autem quibusdam et aut officiis debitis aut rerum necessitatibus saepe eveniet ut et voluptates repudiandae sint et molestiae non recusandae. Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat."

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Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.

The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.

The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.

Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.

The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.

The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.

Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.

The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.

The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.

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"Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?"

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Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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News & Updates

Posts list

If you are a healthy volunteer aged 18+, then you may be eligible to participate in a study investigating a new drug being developed for potential treatment for different types of cancer, including cancers involving the blood and cancers which result in the formation of tumours. 

*Terms & Conditions apply.

Maximum Study Payment: £5300

Study Information

Simbec-Orion Clinical Pharmacology is running a study to investigate the study drug, IOA-244 (also known as roginolisib). 

IOA-244 is being developed as a potential treatment for different types of cancer, including cancers involving the blood (e.g., leukaemia and lymphoma) and cancers which result in the formation of tumours classified as solid tumours (e.g., breast and lung cancer).

Currently, there are various different treatments available for these types of cancer; however these are often associated with side effects and cause widespread effect/damage on the non-cancerous cells and tissue in the body.

Therefore, there is an unmet need to develop more effective treatments that can actually specifically only target the cancer cells, and which have reduced overall side effects. 

The main objectives of the study are as follows:

To investigate the effect of food on the concentration of IOA-244 in the blood following administration of IOA-244 in both a fasted state (without food) and fed state (following a high-fat, high-calorie meal) at two different dose strengths. Also to determine the safety and tolerability of IOA-244 when it is administered in a fasted state and fed state.

As well as evaluating the above, we will also investigate, as exploratory objectives, the levels of IOA-244 in the urine and faeces (stool) and measure the levels of specific markers associated with the study drug and its’ effect on the body.

To evaluate the effect of IOA-244 on the body (known as pharmacodynamics) by analysing the levels of specific biomarkers in the body. Also to investigate the concentration of IOA-244 in the blood, how this changes over a period of time and to measure if and how this concentration differs when IOA-244 is administered at two different dose strengths.

Study Timeline

The purpose of the study is to evaluate the study objectives described above when IOA-244 is given as a single dose at two different dose strengths and in the presence and absence of food across two treatment periods. The study will consist of up to 32 participants with each participant required to complete both treatment periods.  

Across the two treatment periods, each participant will receive:

  • A single dose of IOA-244 (40 or 80 milligrams (mg)) in the form of oral capsules in a fasted state, 
  • A single dose of IOA-244 (40 or 80 mg) in the form of oral capsules following a high-fat, high-calorie meal. There will be at least 6 days between each dose in each treatment period. 

You should note that due to the way that the study is scheduled in the clinical unit, treatment periods 1 & 2 will be conducted sequentially with no discharge from the clinical unit. This means that you will be required to stay at the clinical unit for the following overnight stays: 

Treatment Periods 1 & 2 – total of 13 days with 12 overnight stays 

In addition, the timing of the post-study follow up visit may be extended from 5-7 days post-dose if the data generated during the study indicates that it is necessary to do so (you will be informed as to whether this is the case and subsequently when the post-study follow up visit will take place).

In addition, as the treatment periods will run on consecutive days, the procedures to be performed on Day -1 of each treatment period will only be performed on Day -1 of treatment period 1 i.e., the day on which you will be admitted to the clinical unit. Therefore, you should ensure that you are available to complete all required visits and overnight stays before agreeing to participate in the study as these visits are not flexible. 

If you complete this part of the study, you will receive a maximum inconvenience payment of £5300.

1914 translation by H. Rackham

06/12/2023

“On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue; and equal blame belongs to those who fail in their duty through […]

Read

Section 1.10.33 of “de Finibus Bonorum et Malorum”, written by Cicero in 45 BC

06/12/2023

“At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, […]

Read

News item from Simbec-Orion

06/12/2023

Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272. The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and […]

Read

Section 1.10.32 of “de Finibus Bonorum et Malorum”, written by Cicero in 45 BC

06/12/2023

“Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque […]

Read

The standard Lorem Ipsum passage, used since the 1500s

06/12/2023

“Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat […]

Read

What is Lorem Ipsum?

05/12/2023

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into […]

Read

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