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"On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue; and equal blame belongs to those who fail in their duty through weakness of will, which is the same as saying through shrinking from toil and pain. These cases are perfectly simple and easy to distinguish. In a free hour, when our power of choice is untrammelled and when nothing prevents our being able to do what we like best, every pleasure is to be welcomed and every pain avoided. But in certain circumstances and owing to the claims of duty or the obligations of business it will frequently occur that pleasures have to be repudiated and annoyances accepted. The wise man therefore always holds in these matters to this principle of selection: he rejects pleasures to secure other greater pleasures, or else he endures pains to avoid worse pains."

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"At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus. Temporibus autem quibusdam et aut officiis debitis aut rerum necessitatibus saepe eveniet ut et voluptates repudiandae sint et molestiae non recusandae. Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat."

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Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.

The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.

The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.

Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.

The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.

The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.

Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.

The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.

The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.

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"Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?"

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"Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum."

" ["post_title"]=> string(54) "The standard Lorem Ipsum passage, used since the 1500s" ["post_excerpt"]=> string(0) "" ["post_status"]=> string(7) "publish" ["comment_status"]=> string(4) "open" ["ping_status"]=> string(4) "open" ["post_password"]=> string(0) "" ["post_name"]=> string(53) "the-standard-lorem-ipsum-passage-used-since-the-1500s" ["to_ping"]=> string(0) "" ["pinged"]=> string(0) "" ["post_modified"]=> string(19) "2023-12-06 11:52:48" ["post_modified_gmt"]=> string(19) "2023-12-06 11:52:48" ["post_content_filtered"]=> string(0) "" ["post_parent"]=> int(0) ["guid"]=> string(37) "http://http://researchuk.co.uk/?p=242" ["menu_order"]=> int(0) ["post_type"]=> string(4) "post" ["post_mime_type"]=> string(0) "" ["comment_count"]=> string(1) "0" ["filter"]=> string(3) "raw" } [5]=> object(WP_Post)#11636 (24) { ["ID"]=> int(228) ["post_author"]=> string(1) "1" ["post_date"]=> string(19) "2023-12-05 10:51:17" ["post_date_gmt"]=> string(19) "2023-12-05 10:51:17" ["post_content"]=> string(643) "

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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"On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue; and equal blame belongs to those who fail in their duty through weakness of will, which is the same as saying through shrinking from toil and pain. These cases are perfectly simple and easy to distinguish. In a free hour, when our power of choice is untrammelled and when nothing prevents our being able to do what we like best, every pleasure is to be welcomed and every pain avoided. But in certain circumstances and owing to the claims of duty or the obligations of business it will frequently occur that pleasures have to be repudiated and annoyances accepted. The wise man therefore always holds in these matters to this principle of selection: he rejects pleasures to secure other greater pleasures, or else he endures pains to avoid worse pains."

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News & Updates

Posts list

If you are a healthy male aged between 18 and 64, then you may be eligible to participate in a study investigating a new drug being developed for the potential treatment of premature ejaculation.

*Terms & Conditions apply.

Study Information

Simbec-Orion Clinical Pharmacology will soon be running a five-part study to investigate a drug called KH-001.

The overall objectives of the study are to determine the safety, tolerability (degree to which side effects of a drug can be tolerated) and concentration in the blood and urine (urine for Part B & Part D only – considered as optional analysis) of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, administration in the presence and absence of food and administration of the drug in different forms. The study also aims to evaluate the effect of the study drug on the body, particularly assessing the effect of the drug on overall mood state, including suicidal behaviour.

Blood and urine samples (urine for Part B and Part D only – considered as optional analysis) will be taken at set time points throughout each part of the study in order to measure the concentration of KH-001 in the blood and urine (as applicable).

In the context of the whole study, we will analyse the results from each of the groups and each study part and combine this information in order to better understand how KH-001 works in the body following assessment of different factors within each study part i.e., single and multiple doses, different dose strengths, different dose forms, in the presence and absence of food and comparing between a plant-based (botanical) and man-made (synthetic) version of the drug.

KH-001 is being developed as a potential treatment for a condition known as premature ejaculation (a condition characterised by ejaculation within 1-2 minutes of initiating sexual intercourse). Currently, there are limited treatment options available for this condition with treatments often associated with side effects. Therefore, there is an unmet need to develop more effective treatments that can be used long-term with reduced side effects.

This study will be split into five separate parts, and you will only participate in one part of the study (with the exception of participants in Groups 1-3 of Part A who may be invited to also take part in Part C).

Part A

The purpose of Part A is to evaluate the study objectives when KH-001 is given as a single dose on one occasion at different dose strengths.

Part A will consist of 4 planned groups of up to 8 participants (with the option to include a maximum of 2 additional groups with up to 8 participants each): each group will evaluate a different dose of KH-001 starting at the lowest dose and gradually increasing in each group. This is known as a single ascending dose (SAD) study. Each group will receive KH-001 or a placebo (which contains no active drug) in the form of an oral liquid which participants will swallow

If you participate in this part of the study, you will be required to stay at the Simbec-Orion clinical unit for a period of 3 days (2 overnight stays – Day -1 to Day 2) for the treatment period, followed by a post-study follow-up visit 5-7 days following the last dose of KH-001.You should therefore ensure that you are able to commit to completing all visits before agreeing to participate in this study. You should also note that the timing of the post-study follow up visit may be extended from 5-7 days post-dose if the data generated during the study indicates that it is necessary to do so (you will be informed as to whether this is the case and subsequently when the post-study follow up visit will take place).

the treatment period for this part of the study will require you to stay overnight at the clinical unit for 2 overnight stays. Therefore, you should ensure that you are available to complete all required visits and overnight stays before agreeing to participate in the study.

In addition, the timing of the post-study follow up visit may be extended from 5-7 days post-dose if the data generated during the study indicates that it is necessary to do so (you will be informed as to whether this is the case and subsequently when the post-study follow up visit will take place).

If you complete this part of the study, you will receive a maximum inconvenience payment of £1275.

Part B

The purpose of Part B is to evaluate the study objectives when KH-001 is given as a single dose once daily for a period of five days at different dose strengths.

Part B will consist of 2 planned groups of up to 9 participants (with the option to include a maximum of 2 additional groups with up to 9 participants each): each group will evaluate a different dose based on doses which have been evaluated in Part A of the study (where single doses at different dose strengths were given). Each group will receive KH-001 or a placebo (which contains no active drug) in the form of an oral liquid which participants will swallow.

If you participate in this part of the study, you will be required to stay at the Simbec-Orion clinical unit for a period of 7 days (6 overnight stays – Day -1 to Day 6) for the treatment period, followed by a post-study follow-up visit 5-7 days following the last dose of KH-001.You should therefore ensure that you are able to commit to completing all visits before agreeing to participate in this study. You should also note that the timing of the post-study follow up visit may be extended from 5-7 days post-dose if the data generated during the study indicates that it is necessary to do so (you will be informed as to whether this is the case and subsequently when the post-study follow up visit will take place).

The treatment period for this part of the study will require you to stay overnight at the clinical unit for 6 overnight stays. Therefore, you should ensure that you are available to complete all required visits and overnight stays before agreeing to participate in the study.

In addition, the timing of the post-study follow up visit may be extended from 5-7 days post-last dose if the data generated during the study indicates that it is necessary to do so (you will be informed as to whether this is the case and subsequently when the post-study follow up visit will take place).

If you complete this part of the study, you will receive a maximum inconvenience payment of £2825.

Study Payment: £1275 to £2825 Apply. Be amazing

1914 translation by H. Rackham

06/12/2023

“On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue; and equal blame belongs to those who fail in their duty through […]

Read

Section 1.10.33 of “de Finibus Bonorum et Malorum”, written by Cicero in 45 BC

06/12/2023

“At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, […]

Read

News item from Simbec-Orion

06/12/2023

Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272. The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and […]

Read

Section 1.10.32 of “de Finibus Bonorum et Malorum”, written by Cicero in 45 BC

06/12/2023

“Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque […]

Read

The standard Lorem Ipsum passage, used since the 1500s

06/12/2023

“Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat […]

Read

What is Lorem Ipsum?

05/12/2023

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into […]

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