"On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue; and equal blame belongs to those who fail in their duty through weakness of will, which is the same as saying through shrinking from toil and pain. These cases are perfectly simple and easy to distinguish. In a free hour, when our power of choice is untrammelled and when nothing prevents our being able to do what we like best, every pleasure is to be welcomed and every pain avoided. But in certain circumstances and owing to the claims of duty or the obligations of business it will frequently occur that pleasures have to be repudiated and annoyances accepted. The wise man therefore always holds in these matters to this principle of selection: he rejects pleasures to secure other greater pleasures, or else he endures pains to avoid worse pains."
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" ["post_title"]=> string(78) "Section 1.10.33 of "de Finibus Bonorum et Malorum", written by Cicero in 45 BC" ["post_excerpt"]=> string(0) "" ["post_status"]=> string(7) "publish" ["comment_status"]=> string(4) "open" ["ping_status"]=> string(4) "open" ["post_password"]=> string(0) "" ["post_name"]=> string(75) "section-1-10-33-of-de-finibus-bonorum-et-malorum-written-by-cicero-in-45-bc" ["to_ping"]=> string(0) "" ["pinged"]=> string(0) "" ["post_modified"]=> string(19) "2023-12-06 11:54:01" ["post_modified_gmt"]=> string(19) "2023-12-06 11:54:01" ["post_content_filtered"]=> string(0) "" ["post_parent"]=> int(0) ["guid"]=> string(38) "http://https://researchuk.co.uk/?p=248" ["menu_order"]=> int(0) ["post_type"]=> string(4) "post" ["post_mime_type"]=> string(0) "" ["comment_count"]=> string(1) "0" ["filter"]=> string(3) "raw" } [2]=> object(WP_Post)#14437 (24) { ["ID"]=> int(246) ["post_author"]=> string(1) "1" ["post_date"]=> string(19) "2023-12-06 11:53:42" ["post_date_gmt"]=> string(19) "2023-12-06 11:53:42" ["post_content"]=> string(2477) "The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.
The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.
Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.

The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.
The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.
Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272.
The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and following administration in two different forms.
The study also aims to evaluate the effect of the study drug on the body, through the collection of blood samples at different times through the day.
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" ["post_title"]=> string(54) "The standard Lorem Ipsum passage, used since the 1500s" ["post_excerpt"]=> string(0) "" ["post_status"]=> string(7) "publish" ["comment_status"]=> string(4) "open" ["ping_status"]=> string(4) "open" ["post_password"]=> string(0) "" ["post_name"]=> string(53) "the-standard-lorem-ipsum-passage-used-since-the-1500s" ["to_ping"]=> string(0) "" ["pinged"]=> string(0) "" ["post_modified"]=> string(19) "2023-12-06 11:52:48" ["post_modified_gmt"]=> string(19) "2023-12-06 11:52:48" ["post_content_filtered"]=> string(0) "" ["post_parent"]=> int(0) ["guid"]=> string(38) "http://https://researchuk.co.uk/?p=242" ["menu_order"]=> int(0) ["post_type"]=> string(4) "post" ["post_mime_type"]=> string(0) "" ["comment_count"]=> string(1) "0" ["filter"]=> string(3) "raw" } [5]=> object(WP_Post)#14749 (24) { ["ID"]=> int(228) ["post_author"]=> string(1) "1" ["post_date"]=> string(19) "2023-12-05 10:51:17" ["post_date_gmt"]=> string(19) "2023-12-05 10:51:17" ["post_content"]=> string(643) "Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.
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Study Testimonial
From Our First Volunteer Dosed
Simbec-Orion Clinical Pharmacology, out of our Merthyr Tydfil facility, will soon be running a study to investigate the study drug, P2-101 (active ingredient adrenaline in the form of tablet which dissolves under the tongue) in comparison with the very common injectable form of adrenaline (administered as an injection directly into the muscle) used in the treatment of severe allergic reactions (such as Anaphylaxis) and a placebo treatment (containing no active study drug).
The main objectives of the study are as follows:
Blood samples and other measures as described will be taken at set time points throughout the study to measure the effectiveness of P2-101 in comparison with the adrenaline injection. In the context of the whole study, we will analyse the results from each of the treatment periods and combine this information in order to better understand how P2-101 works in the body and to determine how comparably effective P2-101 is when used in the treatment of allergic reaction. The purpose of the data generated in this study is to provide further information and guidance to support the study Sponsor in the development of the study drug, P2-101
P2-101 is being developed for the treatment of severe allergic reactions. Currently, there are multiple injectable forms of adrenaline available which are used in the treatment of severe allergic reactions and anaphylaxis including systems such as EpiPen®; however, these are not always the easiest of products to use and are often expensive so are not accessible to all individuals who may require this type of product to manage their condition. Therefore, there is an unmet need to develop potential new formulations of adrenaline which could be more effective and reduce these challenges.
If you require any further information or would like to speak with a member of the team before applying please see contact details at the bottom of this page. On successful application you will receive the full clinical study information sheet and consent form, to aid any questions and queries you may have about participating in this trial.
Purpose and Timeline
The purpose of the study is to evaluate the study objectives when P2-101, an adrenaline injection and a placebo treatment are administered as single doses across two treatment periods. The study will consist of up to 12 participants who have a known peanut allergy (documented within the last 12 months and confirmed via allergy testing at screening) with a minimum of 10 participants required to complete both treatment periods
Across the two treatment periods, each participant will receive:
Prior to dose administration in each treatment period, participants will be required to undertake a food challenge whereby they will be asked to eat a food product containing peanuts (e.g., peanut cookies or peanut powder as a paste in natural yoghurt) to trigger an allergic reaction.
Screening Visit
Day -35 to Day -2
Treatment Period One
Day -1 (admission) to Day 1 (discharge).
Treatment Period Two
Day -1 (admission) to Day 1 (discharge)
Post Study Follow-up Telephone Call
5 to 7 days following you last dose.
06/12/2023
“On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue; and equal blame belongs to those who fail in their duty through […]
Read06/12/2023
“At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, […]
Read06/12/2023
Simbec-Orion Clinical Pharmacology will soon be running a two part study to investigate a drug called MB272. The overall objectives of the study are to determine the safety, tolerability and concentration in the blood of the study drug when evaluated in different conditions i.e., different dose strengths, following administration of single and multiple doses, and […]
Read06/12/2023
“Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque […]
Read06/12/2023
“Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat […]
Read05/12/2023
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into […]
ReadHelp us discover, develop and deliver tomorrow’s treatments
You must be registered with us to participate in our clinical studies. Simply complete the online application, it takes around 4 minutes and 33 seconds to become a volunteer.